11 GHP International Life Sciences Awards 2022 As an extended follow-up of this first study, a new trial conducted with good fitness university students revealed that TetraSOD® supplementation induced favorable changes not only on anthropometric and hematological but also on hormonal levels. By the other side, additional clinical trials in trained subjects showed the capacity of TetraSOD®: i) to improve recovery, to sustain power, and to prevent declines in strength across repeated endurance and cross-training bouts, and to reduce muscle damage, ii) to improve perceptual and functional indices of exercise recovery in individuals following a non-functional overreaching resistance-training programme, and iii) to prevent decrements in indices of functional exercise recovery and immune function in subjects following a high-intensity resistance-training programme. According to results in a mechanistic rat model, these outcomes in humans could be prompted by modulating the oxidative stress and pro-inflammatory cytokine response, as well as through up-regulation of positive and down-regulation of negative myogenic factors. In an animal model of induced metabolic syndrome, which is characterized by chronic oxidative stress and low-grade inflammation, dietary TetraSOD® supplementation promoted endogenous antioxidant defence mechanisms in liver, modulated oxidative stress and inflammatory markers in plasma, and regulated genes involved in antioxidant, anti-inflammatory and immunomodulatory pathways in liver, adipose tissue, thymus, and spleen. Lastly, to date, there is no evidence that plant-derived SOD can be absorbed intact and bioactive. Elegant human muscle cell models have revealed a unique signaling effect of TetraSOD®, which may explain its observed antioxidant effects: inducing expression of the antioxidant response element known as NRF2, a nexus within the antioxidant network. The same study revealed an induction of primary antioxidant enzyme activities (SOD, GPX and CAT), which was further related to transcriptional up-regulation of a selected set of genes involved in response against oxidative stress, including NRF2 and HMOX1. *All scientific papers justifying the results here described are available upon request. Given TetraSOD®’s great stability, it can be used for most delivery systems. At the moment is being formulated for finished products used for applications to different health challenges which are affected by cellular oxidative stress. Another fundamental advantage of TetraSOD® is the very small daily dosage needed, with 25 mg for a full spectrum of health benefits from TetraSOD® supplementation. Ultimately, TetraSOD® is much more than just SOD. Contact: [email protected] Closed photobioreactors in land-based microalgae farm TetraSOD® is a novel, natural marine microalgae (Tetraselmis chuii; T. chuii)- derived bioactive that influences antioxidant, anti-inflammatory, hematologic, and metabolic/bioenergetic systems, as well as immune function.Theclosedphotobioreactor production system leverages patent pending, metabolism engineered growth conditions that are highly sustainable, honor the principles of green chemistry, and remove the need for bioengineering of this special strain, indigenous to the Spanish coast. Preclinical and clinical studies continue to reveal and validate its low dose yet potent, pleiotropic effects, impacting antioxidant response, body composition, muscular endurance, and carbohydrate metabolism/ glucose disposal. Microalgae comprise a biomass that has been the focus of numerous ingredient innovations e.g. Chlorella, Spirulina, and Haematococcus species. TetraSOD® is produced by harnessing the robust metabolic, “bioreactor” flexibility of a proprietary strain of T. chuii and cultured in cutting edge Photobioreactor technology, resulting in a complex powder that is concentrated in and standardized to antioxidant enzyme activity, including superoxide dismutase (SOD). TetraSOD® is at the vanguard of microalgae innovation in relation to human nutrition, forging sustainable green chemistry with a preclinical and clinical strategic research program, and expanding the palette of bioactivities and salutary effects. Fitoplancton Marino, S.L. is the company behind this unique ingredient, for more than 15 years one of the world’s leading marine microalgae producers. TetraSOD® is the most complete and comprehensive ingredient for the Healthy Ageing nutraceutical category but also offers athletes and individuals with active lifestyles an increased physiological response against oxidative stress to aid performance and recovery, all in a small, concentrated dose. SOD is the first essential enzyme in the antioxidant pathway, which makes it the first shield against oxidative stress; TetraSOD® is the most concentrated SOD source in the market, with science backed demonstrated efficiency on activating the antioxidant response pathway on human cells. A controlled, university-based human study in elite, young football players reported that daily supplementation with 25 mg of TetraSOD® elicited significantly greater and favorable changes in maximal endurance capacity and ergoespirometric values, body composition, blood markers of oxidative stress, and blood hemoglobin, unaccompanied by an increase in blood viscosity. TetraSOD®, a unique marine ingredient Jun22319
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